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Metalloproteinase inhibitor 1 ( TIMP1 ) Antibody Datasheet
 
 
 
TIMP1抗体产品信息
 
 
 
 
免疫原 : 
 
 
Recombinant human TIMP1 protein ( Catalog #10934-H08H )
 
 
 
 
抗体宿主 :
 
 
Rabbit  IgG
 
 
 
 
缓冲液 :
 
0.2 μm filtered solution in PBS with 5% trehalose
 
 
 
制备方法 : 
 
 
Produced in rabbits immunized with purified, human cell-derived, recombinant human TIMP1 ( rhTIMP1; Catalog #10934-H08H; NP_003245.1; Met 1-Ala 207 ). TIMP1 specific IgG was purified by human TIMP1 affinity chromatography.
 
 
 
 
 
TIMP1抗体使用指南
 
 
 
 
 
特异性 : 
 
 
 
Human  TIMP1
 
 
 
 
Western blot : 
 
This antibody can be used at 0.1 - 0.2 μg/mL with the appropriate secondary reagents to detect TIMP1. Using a DAB  detection system, the detection limit for TIMP1 is approximately 0.5ng/lane under non-reducing conditions and 2ng/lane under reducing conditions.
 
 
 
储存方法 :
 
This antibody can be stored at 2℃-8℃ for 1 month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
 Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly.
 Avoid repeated freeze-thaw cycles.
 
 
 
 
 TIMP1 Antibody Related Products & Topics
 
 
相关研究领域:
 
Enzyme>>Protease & Regulator>>Metalloprotease & Regulator>>Tissue Inhibitor of Metalloproteinase>>TIMP-1/TIMP1
 
Cancer>>Angiogenesis>>Tissue Inhibitor of Metalloproteinase>>TIMP-1/TIMP1
 
Cancer>>Cancer Biomarkers>>TIMP-1/TIMP1
 
蛋白:
 
 
 
 
Molecule
 
Species
 
Description //For Detailed Info.------CLICK!
 
Cat No
 
 
 
TIMP-1/TIMP1
 
Human
 
TIMP-1/TIMP1 Protein, Recombinant  
 
10934-H08H
 
 
 
TIMP-1/TIMP1
 
Human
 
TIMP1/TIMP1 Protein, Recombinant  
 
10934-HNAH
 
 
 
TIMP-1/TIMP1
 
Mouse
 
TIMP-1/TIMP1 Protein, Recombinant  
 
50342-MNAH
 
 
 
 
抗体:
 
 
 
 
Molecule
 
Application
 
Description //For Detailed Info.------CLICK!
 
Cat No
 
 
 
Human TIMP-1/TIMP1
 
ELISA
 
Mouse Monoclonal Antibody
 
10934-MM02
 
 
 
Human TIMP-1/TIMP1
 
WB, ELISA
 
Mouse Monoclonal Antibody
 
10934-MM03
 
 
 
Human TIMP-1/TIMP1
 
ELISA
 
Rabbit Polyclonal Antibody
 
10934-RP01
 
 
 
Human TIMP-1/TIMP1
 
WB
 
Rabbit Polyclonal Antibody Antigen Affinity Purified)
 
10934-RP04
 
 
 
 
 
 TIMP1抗体背景综述
 
 
Tissue inhibitors of metalloproteinases (TIMP) family are natural inhibitors of the matrix metalloproteinases (MMPs), the zinc enzymes involved in extracellular matrix maintenance and remodeling. The TIMP family encompasses four members (TIMP1-4), and the inducible form TIMP1 is a glycoprotein expressed by a variety of cell types. It inhibits most MMPs except membrane-type MMP subfamily by forming non-covalent binary complex, but also interacts with the hemopexin-like (PEX) domain of pro MMP-9. TIMP1 has been identified as a multifunctional molecule with divergent functions. It exhibits keratinocyte and fibroblast growth factor-like activity and acts as a cell survival factor, and additionally participates in tumor metastasis, angiogenesis, inflammatory responses, as well as CNS homeostasis. TIMP-1 overexpression may serve to help identify patients with particularly aggressive disease for adjuvant treatments.
 
 
参考文献
 
 
1.  Osthues, A. et al., 1992, FEBS. Lett. 296: 16-20.
 
2.  Aljada, I.S. et al., 2004, J. Clin. Oncol. 16: 3218-29.
 
3.  Hornebeck, W. 2004, Pathol. Biol. 51: 569-73.
 
4.  Gardner, J and Ghorpade, A. 2003, J. Neurosci. Res. 74: 801-6.
 
 
 
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