Anti-CHM Polyclonal Antibody
产品名称: Anti-CHM Polyclonal Antibody
英文名称: TCD;GGTA;REP-1;DXS540;HSD-32
产品编号: K008000P
产品价格: null
产品产地: 北京
品牌商标: Solarbio
更新时间: null
使用范围: IHC
北京索莱宝科技有限公司--实验室产品
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This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene.